Grade 7 (£31,604 - £38,883)
Closing Date: 13 October 2017
DNA repair mechanisms and human disease
The Rouse lab is interested in how cells sense, signal and repair damaged DNA, and how they cope when DNA damage – or other obstacles – blocks the process of DNA replication. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation. Disrupting DNA repair causes human disease, and yet inhibiting DNA repair pathways acutely is an important way of destroying tumours. In this light, several of the most commonly used chemotherapeutic agents destroy tumours by inducing DNA damage.
We are looking for a bright enthusiastic individual to join our tern to study how cells repair damaged DNA. The Rouse team has a track record in identifying and characterising new regulators of DNA repair including the FAN1 nuclease (Cell 142, 65-76; Science 351, 846-849; Genes Dev. 30, 639-644), the SLX4 complex of nucleases (Mol. Cell 35, 116-127), the MMS22L-TONSL complex (Mol. Cell 40, 632-644) and DVC1 (Nat. Struct. Mol. Biol. 19, 1093-1100), and most recently a new Fanconi anemia gene RFWD3 (Mol. Cell 66, 610-621). We use a range of approaches – biochemistry, genetics and cell biology – to tackle the questions we are trying to answer.
Informal enquiries or applications should be directed to Professor John Rouse at firstname.lastname@example.org
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).
Additional InformationThe University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.
The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.
The University of Dundee is a Scottish Registered Charity, No. SC015096.
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