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Reference Number SLSC0774
Job Title Senior Biologist (Tuberculosis)
College/SASS School of Life Sciences
School/Directorate Drug Discovery Unit
Grade Grade 8 (£41,526 - £49,553)
Job Category Research
Closing Date 25 September 2020
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

We have an exciting and challenging opportunity for a highly motivated and experienced biologist to join our drug discovery team. The appointee will be involved in leading the biology aspects of a portfolio of drug discovery projects for tuberculosis (TB). They will be responsible for integrating results from our TB biology collaborators with the chemistry, computational chemistry and pharmacokinetic aspects of the program. The successful candidate will gain valuable experience in working with some of the world’s leading TB biologists as part of the TB Drug Accelerator, a unique collaboration between industry and academia aiming to identify novel TB therapeutics.

The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery operation based within a world class Life Sciences research environment. The DDU works on both neglected diseases (TB, malaria, cryptosporidiosis, leishmaniasis and Chagas disease) and validation of novel drug targets across a range of therapeutics areas. The DDU works to Biotech style philosophy and standards, incorporating dynamic, goal driven project management. The DDU has a proven track record of delivery of pre-clinical candidates for neglected diseases.

The TB Portfolio ranges from hit ID, using both phenotypic and target-based approaches, through to identification of preclinical candidates, carried out by a team of ~15 scientists and enabled by ~$8 million of funding and multiple international collaborations with Pharma companies and leading research organisations. Currently the project has a range of projects from candidate selection phase and late lead optimisation to hit validation and target-based screening.

The post is available for an immediate start. The salary will be between £41,526 and £49,533, depending on experience.
Required attributes:
  • Candidates must have a PhD in a biological science related discipline, or alternatively a BSc in a biological science with subsequent substantial experience.
  • Ideally a candidate would have experience of both drug discovery and TB (or other anti-bacterial research), however we would accept candidates with a significant track record of working in one of the following areas:
    •  only drug discovery projects, in particular in multidisciplinary interactions between biology, pharmacology, computational/structural biology and medicinal chemistry and be able to evidence their influencing strategy or tactics applied to advance a project.
    • TB biology particularly exploring the mechanism of action of compounds.
  • Candidates will have a track record of answering research questions by applying multiple complementary techniques and approaches by engaging with external experts.
  • Candidates will have a broad understanding of cellular biology and enzymology sufficient to propose approaches in either discipline to advance projects.
  • Strong interpersonal, communication and presentation skills.
  • Ability to take the initiative.
Preferred attributes:
  • General microbiology skills.
  • Experience in setting up, optimising, and running a variety of biochemical and cellular assays, as evidenced through publications and/ or preclinical candidates.
  • Experience in line management.

For further information about this position please contact Professor Paul Wyatt at p.g.wyatt@dundee.ac.uk. To find out more about the Drug Discovery Unit, please visit our website.
 
The Drug Discovery Unit operates on an external funding basis. The Principal Investigators within this unit are highly successful in securing external funding for their multi-disciplinary and highly collaborative research and activities. 
 
A few facts about The School of Life Sciences at Dundee:
  • The School of Life Sciences has over 1000 research and support staff from around 60 countries and external funding in excess of £100 million in 2013
  • Dundee has twice been named 'the best place to work in Europe' in a poll of scientists conducted by The Scientist magazine.
  • Life Sciences at the University of Dundee is the highest-rated for Biological Sciences in the UK by the main standard of University research performance REF2014.
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology.

Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee is also a vibrant cultural centre. Home to the new V&A Dundee, opened in September 2018 and already hosting its 500,000th visitor; the Dundee Rep and Scottish Dance Theatre; Dundee Contemporary Arts; MacManus Gallery and many individual artists.

For further information about the local area and the top reasons to live and work in Dundee and Scotland;

https://www.visitscotland.com/ebrochures/en/what-to-see-and-do/perthshireanddundee/

https://www.talentscotland.com/live/lifestyle/top-reasons-to-live-and-work-in-scotland

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.
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